Boron tribromide → HCID 57708912, compound

Participants

Reaction Conditions

Reaction Steps

A 1 M solution of boron tribromide in dichloromethane (0.15 mL, 0.15 mmol) was added to a solution of {4′-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2′-methoxy-biphenyl-4-yl}-acetic acid methyl ester (Example 176-(7); 20 mg, 0.0366 mmol) in dichloromethane (0.2 mL) at −78° C., and the mixture was stirred at −78° C. for 30 minutes. The reaction mixture was poured into a saturated aqueous sodium bicarbonate solution, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane only to hexane:ethyl acetate=3:1) to give the title compound (10.8 mg, 55%).

Provenance & Evidence