反应详情

温度

80 °C

A solution of hydrazine (103 mg, 3.21 mmol) in acetic acid (16 mL) was added to (2,5-dioxo-2,5-dihydro-furan-3-yl)acetic acid (500 mg, 3.04 mmol) under cooling with ice, and the mixture was heated with stirring at an external temperature of 76 to 84° C. for one hour. The reaction mixture was concentrated under reduced pressure. The resulting solid was sequentially washed with water, ethanol and ether to give the title compound (414 mg, 80%).

1. temperatureunder cooling with ice
2. temperaturethe mixture was heated
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. washThe resulting solid was sequentially washed with water, ethanol and ether