反应详情

2.0 g (9 mmol) of 3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid were dissolved in 26.5 ml (267 mmol) of isobutylamine. The mixture was heated at reflux with stirring for 8 days, cooled to RT, acidified with 10% strength sulfuric acid and extracted twice with ethyl acetate. The combined organic phases were dried over MgSO4, and the solvent was removed under reduced pressure. This gave 2.4 g of a colorless solid of a purity of 98%.

1. temperatureThe mixture was heated
2. temperatureat reflux
3. extractionextracted twice with ethyl acetate
4. dry with materialThe combined organic phases were dried over MgSO4
5. customthe solvent was removed under reduced pressure