Trifluoroacetic acid → HCID 25117679, compound

Participants

Reaction Steps

tert-Butyl {(3R)-1-[1-methyl-3-(naphthalen-1-ylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-yl}carbamate (0.200 g, 0.395 mmol) was dissolved in dichloromethane and to this was added trifluoroacetic acid (1 mL). The reaction mixture was stirred at room temperature over night. The solvent and excess trifluoroacetic acid was evaporated and the residue was dissolved in ethyl acetate. The organic mixture was washed with saturated aqueous potassium carbonate. The solvent was evaporated to afford a pure (3R)-1-[1-methyl-3-(naphthalen-1-ylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine (15, 0.147 g, 92%).

Provenance & Evidence