HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl pyrrolidine-2-carboxylic acid benzyl ester → 1-ethyl-L-Proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl pyrrolidine-2-carboxylic acid benzyl ester | HCID 3449739 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-ethyl-L-Proline | HCID 28354718 | 76% |
Reaction Steps
A suspension of 1-ethyl pyrrolidine-2-carboxylic acid benzyl ester (1.5 g, 6.43 mmol) and 10% Pd on charcoal in methanol (30 mL) was hydrogenated over 12 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated to get title product (700 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939513B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-1c3ed9e138bd4753a9071095cbb99fee |
| Source note | uspto-grants-2011_05 |