HCID 67198615, compound → HCID 25312263, compound

HRID 547264Notes

Reaction equation

HRID 547264 reaction equation
C([O:8][C:9]([CH:11]1[CH2:15][CH2:14][CH2:13][N:12]1[CH2:16][CH2:17][CH3:18])=[O:10])C1C=CC=CC=1>CO.[Pd]>[CH2:16]([N:12]1[CH2:13][CH2:14][CH2:15][C@H:11]1[C:9]([OH:10])=[O:8])[CH2:17][CH3:18]

Participants

4

Reactant 1

HCID 67198615HCID 67198615, compound

Product 1

HCID 25312263HCID 25312263, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-n-propyl pyrrolidine-2-carboxylic acid benzyl ester (2.0 g, 8.09 mmol) and 10% Pd on charcoal in methanol (30 mL) was hydrogenated over 12 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated (1 g, 77%).

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationthe filtrate was concentrated (1 g, 77%)

Sources & evidence

ORD record
ord-4d0320a9d32344bcaad35ccef4f4450f
Source dataset
uspto-grants-2011_05
Patent number
US07939513B2

Reaction notes

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