HCID 178482952, compound → HCID 178482951, compound

Participants

Reaction Steps

A suspension of (S)-benzyl 2-((5aR,6aS,7S,10aS)-9-carbamoyl-4,7-bis(dimethylamino)-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-ylcarbamoyl)pyrrolidine-1-carboxylate (200 mg, 0.29 mmol) and 10% Pd on charcoal in methanol (10 mL) was hydrogenated over 1 h. The reaction mixture was filtered through a pad of celite and the filtrate was poured into ether containing HCl to get (S)—N-((5aR,6aS,7S,10aS)-9-carbamoyl-4,7-bis(dimethylamino)-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-yl)pyrrolidine-2-carboxamide (120 mg, 72%).

Provenance & Evidence