Sodium Carbonate → HCID 67198154, compound

Participants

Reaction Steps

To a solution of 2-(3-iodophenyl)propionitrile (0.6 g, 2.33 mmol) in dry THF (10 mL) Pd(PPh3)4 (4% mol, 0.108 mg) and Na2CO3 (0.493 g, 4.66 mmol) were added sequentially under nitrogen atmosphere. After stirring 20 min commercial 1,3-oxazole-2-boronic acid (0.289 g 2.56 mmol) was added. The reaction mixture was stirred at reflux 4 h. After cooling at room temperature, THF was evaporated under reduced pressure and EtOAc (10 mL) was added to the crude and the organic phase was washed with water (3×10 mL) and brine (3×10 mL). After drying over Na2SO4 and solvent evaporation a residue was obtained that, after flash chromatography (eluent mixture n-hexane/EtOAc 8:2), afforded 2-(3-oxazol-2-ylphenyl) propionitrile as yellow oil (0.360 g, 1.82 mmol). Yield 78%.

Provenance & Evidence