Aluminum(III) Chloride → HCID 67200304, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[3-(3-chloropropionylamino)phenyl]propionitrile (0.654 g, 2.77 mmol) in CH2Cl2 (8 mL) at 0° C. AlCl3, (1.10 g, 8.31 mmol) was added portionwise. The reaction mixture was stirred 5 min, then was refluxed 8 h. After cooling at 0° C., the mixture was washed with 6N HCl solution (3×10 mL), water (3×10 mL) and brine (2×10 mL). After drying over Na2SO4 and solvent evaporation a crude residue was obtained that, after flash chromatography (eluent mixture n-hexane/EtOAc 85:15), afforded 2-(2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl]propionitrile as yellow oil (0.345 g, 1.72 mmol). Yield 62%.

Provenance & Evidence