反应详情

Heptanoyl chloride (1 mL, 6.5 mmol) was added dropwise to a solution of N4-{2-[2-(methylsulfonyl)ethoxy]ethyl}quinoline-3,4-diamine (prepared as described in Parts A-E of Example 1, approximately 1.8 g, approximately 5.9 mmol) in acetonitrile (30 mL). The reaction mixture was allowed to stir for 1 hour at room temperature, then was concentrated under reduced pressure to yield N-[4-({2-[2-(methylsulfonyl)ethoxy]ethyl}amino)quinoline-3-yl]heptanamide hydrochloride as an orange foam that was used without purification.

1. concentrationwas concentrated under reduced pressure