HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-(1,3)thiazolo(4,5-b)pyridine | HCID 51358428 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)benzaldehyde | HCID 57448384 | — |
Reaction Steps
To a solution of 2-chloro[1,3]thiazolo[4,5-b]pyridine (25 g, 147 mmol) in CH3CN (500 mL) was added 4-hydroxybenzaldehyde (19.8 g, 147 mmol, 1 equiv.) and K2CO3 (22.3 g, 147 mmol, 1 equiv.). The heterogeneous mixture was heated at reflux for 72 h and then cooled to rt. Purification was conducted using one of the following methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939527B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-22d5a7eaf98c4bce83dcb5d0e468e342 |
| Source note | uspto-grants-2011_05 |