HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 547367Generated: October 27, 2026
Pyrrolidine → 2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)-6-(pyrrolidin-1-yl)nicotinamide
https://huagongshe.com/reaction/547367
Participants
| Role | Name | HCID | Charge |
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| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-chloro-2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)nicotinamide | HCID 59738223 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)-6-(pyrrolidin-1-yl)nicotinamide | HCID 59740847 | — |
Reaction Steps
A mixture of 6-chloro-2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)nicotinamide (50 mg, 0.13 mmol) and pyrrolidine (94 mg, 1.3 mmol) in a sealed tube was heated to 150° C. for 10 min. LC/MS indicated the reaction was complete. The crude was diluted with MeOH, filtered, and purified on RP-HPLC using a mixture of acetonitrile and H2O to a give 2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)-6-(pyrrolidin-1-yl)nicotinamide (20.2 mg, 37%). LRMS (M+H+) m/z 420.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07939534B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-a5e8cf9ffb184397a113f46919162bb0 |
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| Source note | uspto-grants-2011_05 |
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