Potassium Carbonate → HCID 59740842, compound

Participants

Reaction Steps

A mixture of (3-((6-chloro-2-(3-fluorophenethylamino)nicotinamido)methyl)pyridin-2-yl)methylcarbamate (0.10 g, 0.19 mmol), tetrakis(triphenylphosphine)palladium(0) (0.045 g, 0.039 mmol), K2CO3 (0.081 g, 0.59 mmol), cyclopenten-1-yl boronic acid (0.026 g, 0.23 mmol) and NMP (0.2 mL) was sealed in a tube and microwaved at 150° C. for 30 min. The reaction mixture was filtered through a silica plug with EtOAc, washed with H2O, brine, dried (Na2SO4) and concentrated to give tert-butyl (3-((6-cyclopentenyl-2-(3-fluorophenethylamino)nicotinamido)methyl)pyridin-2-yl)methylcarbamate. LC/MS (M+H+) m/z 546.2.

Provenance & Evidence