Hydrochloric Acid → HCID 59740871, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(6-(3-fluorophenethylamino)-5-(pyridin-3-ylmethylcarbamoyl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.377 mmol) in MeOH (8 mL) at 0° C. was added HCl (2.0 mL, 8 mmol, 4 M in dioxane) under nitrogen. The reaction mixture was warmed to room temperatures stirred at r.t. for 4 h. LC/MS indicated the reaction was complete. The reaction mixture was concentrated under reduced pressure to give 2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)nicotinamide which was used for next step without further purification. LRMS (M+H+) m/z 444.2.

Provenance & Evidence