Ammonia → N-(3,4,4-trifluoro-3-butenyl)ethanediamide

HRID 54738Notes

Reaction equation

HRID 54738 reaction equation
O=[C:2]([NH:9][C:10](=[O:15])[C:11](OC)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[NH3:16]>CO>[F:8][C:4](=[C:5]([F:7])[F:6])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([NH2:16])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86748464Oxo[(3,4,4-trifluoro-3-butenyl)amino]oxoacetic acid, methyl ester

Product 1

HCID 15239196N-(3,4,4-trifluoro-3-butenyl)ethanediamideYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Compound 142 (5.0 g, 0.0237 mole) in methanol (50 mL) is saturated with dry gaseous ammonia at room temperature. The precipitate is filtered, washed with methanol and dried to give 3.16 g of the title compound as a white solid, a 68% yield. m.p. 190°-220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-d3e4a86066284cc4a54d36a98b12c0fe
Source dataset
uspto-grants-1997_04
Patent number
US05623084

Reaction notes

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