HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 547385Generated: October 30, 2026
4-Fluorobenzylamine → Benzyl (2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)carbamate
https://huagongshe.com/reaction/547385
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | Methyl 9-{[(benzyloxy)carbonyl]amino}-3-hydroxy-4-oxo-4-H-pyrido[1,2-a]pyrimidine-2-carboxylate | HCID 54751204 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzyl (2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)carbamate | HCID 86761308 | — |
Reaction Steps
To a suspension of methyl 9-{[(benzyloxy)carbonyl]amino}-3-hydroxy-4-oxo-4-H-pyrido[1,2-a]pyrimidine-2-carboxylate in MeOH was added p-fluorobenzylamine. The suspension was stirred at 80° C. and after 16 hours the solvent was removed under reduced pressure. The product was purified by preparative RP-HPLC, using water (0.1% TFA) and acetonitrile (0.1% TFA) as eluants (column: C18). The product was obtained after lyophilization of the pooled product fractions as bright yellow fluffy material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07939537B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-45db45cb4c164866a970a26e573cbc9f |
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| Source note | uspto-grants-2011_05 |
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