4-(2-(4-Bromophenoxy)ethyl)morpholine → 4-(2-(4-(6-Fluoropyridin-3-yl)phenoxy)ethyl)morpholine

HRID 547417Notes

Reaction equation

HRID 547417 reaction equation
Br[C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.B(O)(O)[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[N:20][CH:19]=1>>[F:24][C:21]1[N:20]=[CH:19][C:18]([C:2]2[CH:16]=[CH:15][C:5]([O:6][CH2:7][CH2:8][N:9]3[CH2:14][CH2:13][O:12][CH2:11][CH2:10]3)=[CH:4][CH:3]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 20538154-(2-(4-Bromophenoxy)ethyl)morpholineHCID 2783397(6-Fluoropyridin-3-yl)boronic acid

Product 1

HCID 441854204-(2-(4-(6-Fluoropyridin-3-yl)phenoxy)ethyl)morpholine

Procedure

coupling 4-(2-(4-bromophenoxy)ethyl)morpholine with 6-fluoropyridin-3-yl-3-boronic acid to yield 4-(2-(4-(6-fluoropyridin-3-yl)phenoxy)ethyl)morpholine;

Sources & evidence

ORD record
ord-b688701219ea468e8840d49429635b53
Source dataset
uspto-grants-2011_05
Patent number
US07939529B2

Reaction notes

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