Sodium Hydroxide → HCID 20324415, compound

HRID 547445Notes

Reaction equation

HRID 547445 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][O:14][CH3:15])C.[OH-].[Na+]>CO>[CH3:15][O:14][CH2:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[CH2:5][C:4]([OH:16])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 71362533Ethyl [2-(methoxymethoxy)phenyl]acetate

Product 1

HCID 20324415HCID 20324415, compoundYield 77.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 20 mL of a methanol solution containing 0.69 g of ethyl-(2-methoxymethoxyphenyl)acetate, 16 mL of 1M aqueous sodium hydroxide solution was added and stirred at room temperature for 5 hours. From the reaction liquid the solvent was distilled off under reduced pressure and the residue was rendered acidic with 2M aqueous citric acid solution and extracted with ethyl acetate. The ethyl acetate extract was dried over anhydrous magnesium sulfate and thereafter the solvent therein was distilled off under reduced pressure to provide 0.47 g (yield: 77%) of the title compound as an oily substance.

Workup

  1. additionwas added
  2. customFrom the reaction liquid the solvent
  3. distillationwas distilled off under reduced pressure
  4. extractionextracted with ethyl acetate
  5. extractionThe ethyl acetate extract
  6. dry with materialwas dried over anhydrous magnesium sulfate
  7. distillationthe solvent therein was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4ea1b3c25fad49289c744008ab465a30
Source dataset
uspto-grants-2011_05
Patent number
US07939536B2

Reaction notes

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