Sodium Bicarbonate → HCID 67196687, compound

Participants

Reaction Steps

Fifty (50) mg of 3-(4-fluorophenyl)-5-[(2-methoxymethoxy-phenyl)acetylamino]-4-(4-pyrimidinyl)isoxazole was dissolved in 30 mL of dichloromethane and into which 460 mg of sodium hydrogensulfate reagent as fixed on silica gel was added, followed by 4 hours' stirring at room temperature. After addition of saturated aqueous sodium hydrogencarbonate solution, the reaction solution was extracted with chloroform. The chloroform extract was dried over anhydrous magnesium sulfate and from which the solvent was distilled off under reduced pressure. Thus obtained residue was washed with ether-hexane to provide 16 mg (yield: 34%) of the title compound.

Provenance & Evidence