反应详情

2-Amino-4-chlorobenzoic acid (250 mg, 1 eq.) and N-benzylacetamide (261 mg, 1.2 eq.) were dissolved in phosphorus oxychloride (2 ml). The reaction was placed in the microwave for 10 minutes at 150° C. The reaction was quenched by pouring the mixture into ice. The crude product was extracted into ethyl acetate. The ethyl acetate layer was washed with water, 10% aqueous sodium hydroxide, dried with magnesium sulfate, filtered, and concentrated to yield 3-benzyl-7-chloro-2-methylquinazolin-4 (3H)-one as an orange solid.

1. customThe reaction was quenched
2. additionby pouring the mixture into ice
3. extractionThe crude product was extracted into ethyl acetate
4. washThe ethyl acetate layer was washed with water, 10% aqueous sodium hydroxide
5. dry with materialdried with magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated