HCID 57829682, compound → HCID 44192908, compound

HRID 547478Notes

Reaction equation

HRID 547478 reaction equation
[CH3:1][C:2]([CH3:42])([CH3:41])[C:3]([C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][C:24]([N:26]4[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]4)=[O:25])[CH:15]=3)[N:12]=2)[N:7](COCC[Si](C)(C)C)[CH:6]=1)=[O:4]>C(Cl)Cl.CO>[CH3:1][C:2]([CH3:42])([CH3:41])[C:3]([C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][C:24]([N:26]4[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]4)=[O:25])[CH:15]=3)[N:12]=2)[NH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 57829682HCID 57829682, compound

Product 1

HCID 44192908HCID 44192908, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2,2-Dimethyl-1-(2-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-indol-3-yl}-5H-pyrrolo[2,3-b]pyrazin-7-yl)-propan-1-one was prepared following the same procedure but using 2,2-dimethyl-1-[2-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-indol-3-yl}-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one as starting material. The product was isolated in 67% yield by SiO2 chromatography (DCM/MeOH 0-10% MeOH).

Sources & evidence

ORD record
ord-6a7036773754442f8c4ea655d0a939a7
Source dataset
uspto-grants-2011_05
Patent number
US07939531B2

Reaction notes

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