Sodium Acetate Trihydrate → {2-[5-(4-hydroxy-piperidine-1-carbonyl)-thiophen-2-yl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-(1-methyl-cyclohexyl)-methanone

Participants

Reaction Steps

A solution of [2-[5-(4-hydroxy-piperidine-1-carbonyl)-thiophen-2-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-(1-methyl-cyclohexyl)-methanone (0.032 g, 0.056 mmol) in 1 mL of dichloromethane and 1 mL of trifluoroacetic acid was stirred for 2 h, then concentrated. The residue was dissolved in 2 mL of ethanol and treated with sodium acetate trihydrate (0.076 g, 0.56 mmol). The mixture was stirred overnight, then concentrated to a residue. Column chromatography (0->50% EtOAc/hexanes) afforded 0.019 g (76%) of {2-[5-(4-hydroxy-piperidine-1-carbonyl)-thiophen-2-yl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-(1-methyl-cyclohexyl)-methanone as an off-white solid.

Provenance & Evidence