Ammonia methanol → HCID 59738211, compound

HRID 547504Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([C:14](=[NH:18])OCC)[CH:11]=[CH:10][C:9]=1[C:19](=[O:28])[NH:20][CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.[NH3:32].CO>>[C:14]([C:12]1[CH:11]=[CH:10][C:9]([C:19]([NH:20][CH2:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[O:28])=[C:8]([NH:7][CH2:6][CH2:5][C:4]2[CH:29]=[CH:30][CH:31]=[C:2]([F:1])[CH:3]=2)[N:13]=1)(=[NH:32])[NH2:18]

Participants

Reactant 2

HCID 21705897Ammonia methanol

HCID 59738218HCID 59738218, compound

Product 1

HCID 59738211HCID 59738211, compound

Conditions

Temperature: 50 °C

Procedure

A mixture of the ethyl 6-(3-fluorophenethylamino)-5-(pyridin-3-ylmethylcarbamoyl)picolinimidate and NH3/MeOH (7N, 0.76 mL) was stirred at 50° C. for 1 hour. The reaction mixture was concentrated to dryness to give 6-carbamimidoyl-2-(3-fluorophenethylamino)-N-(pyridin-3-ylmethyl)nicotinamide. LC/MS (M+H+) m/z 394.1.

Workup

concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record: ord-87b1c7d23aa64b2d910cbf181804e941
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07939548B2

Reaction notes

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