Sodium borohydride → HCID 67198422, compound

Participants

Reaction Steps

495 mg (1.8 mM) of 4-nitro-1-phenethyl-1H-pyrazole-3-carboxylic acid ethyl ester was dissolved in 5 ml of methyl alcohol, to which 680 mg (18 mM, 13 eq) of sodium borohydride was added dropwise at 0° C., and the resulting mixture was stirred under a nitrogen atmosphere for 1 hour. The solvent was distilled off under reduced pressure, and the resultant was extracted with ethyl acetate and brine. The organic solvent layer was dried over anhydrous sodium sulfate, filtered, and then distilled under reduced pressure. The resulting impure compound was purified by column chromatography (hexane:ethyl acetate=2:1), to obtain 295 mg (66.4%) of the title compound.

Provenance & Evidence