HCID 59457955, compound → HCID 59457944, compound

Participants

Reaction Steps

Compound 9 (634 mg, 246 mmol) was hydrogenated in MeOH (50 mL) with 10% Pd/C (100 mg) at 45 Hg mm. for 20 h. The reaction mixture was filtered and evaporated to dryness to give 10 (550 mg, 99%); mp (MeOH) 230-233° C.; 1H NMR [(CD3)2SO] δ 8.96 (s, 1 H, NH), 7.70 (d, J=8.7 Hz, 1 H, H-3′), 7.65 (d, J=2.5 Hz, 1 H, H-6′), 6.95 (dd, J=8.8, 2.9 Hz, H-4′), 6.30 (s, 1 H, H-5), 5.94 (s, 2 H, NH2), 4.84 (s, 2 H, NH2), 2.07 (s, 3H, CH3); HRMS (FAB+) calc. for C10H13N6 (M+1) m/z 217.1202, found 217.1202; Anal. calc. for C10H12N6; C, 55.5; H, 5.6; N, 38.9; found C, 55.3; H, 5.7; N, 38.6%.

Provenance & Evidence