Hydrochloric Acid → HCID 67201016, compound

Participants

Reaction Steps

To a suspension of 4-chloroquinoline (0.500 g, 3.06 mmol) and 4-aminobenzoic acid (0.419 g, 3.06 mmol) in 2-propanol (10 mL) 3 drops of concentrated hydrochloric acid were added and mixture was microwave irradiated at 150° C. for 1 hour. After cooling solid was filtered off, washed with 2-propanol and dried in vacuo to give Cpd C as a yellow powder. Purity (HPLC): 100%. 1H NMR (DMSO-d6): 7.05 (d, J=6.9 Hz, 1H), 7.64-7.67 (m, 2H), 7.80-7.85 (m, 1H), 8.02-8.17 (m, 5H), 8.59 (d, J=7.2 Hz, 1H), 8.92 (d, J=8.1 Hz, 1H), 11.26 (s, 1H). MS (ES+): calc. for C16H13N2O2 (MH+) 265.1, found 265.1.

Provenance & Evidence