Trifluoroacetic acid → HCID 67202348, compound

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Reaction Steps

Compound 16 (1.05 g, 2.68 mmol), prepared as described in Section 7.12, was dissolved in CH2Cl2 (40 mL) and treated with TFA (40 mL). The resulting mixture was stirred for 1.5 h then concentrated in vacuo. The concentrate was re-dissolved in CH2Cl2 (100 mL) and washed with saturated NaHCO3 (100 mL). The aqueous wash was extracted with additional CH2Cl2 (3×50 mL). The combined extracts were dried over Na2SO4, concentrated and dried under high vacuum for 17 h to give P1 (767 mg, 98%), which was suitable for use without further purification.

Provenance & Evidence