HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 547588Generated: October 27, 2026
Tetrabutylammonium Fluoride → 1-(3-Hydroxymethyl-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester
https://huagongshe.com/reaction/547588
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | Ethyl 1-[3-(2-tert-butylsilyloxypropan-2-yl)phenyl]imidazole-4-carboxylate | HCID 131728825 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(3-Hydroxymethyl-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester | HCID 57826359 | 79% |
Reaction Steps
To a solution of compound 6 (1.50 g, 4.2 mmol) in THF (18 mL) was added tetrabutylammonium fluoride (1.58 g, 5 mmol) and refluxed at 70° C. for 12 h. After concentration, the residue was purified by filter column using 4% methanol in chloroform to give alcohol 7 (810 mg, 79%) as pale yellow gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07939556B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-a50b76c2934e40d985d86d1abf72369b |
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| Source note | uspto-grants-2011_05 |
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