2-Aminoindane → HCID 178492108, compound

HRID 547630Notes

Reaction equation

HRID 547630 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][C:12]=3[O:19][CH3:20])=[CH:9][C:4]=2[N:3]=[CH:2]1.COC(OC)C1C=CC(OC2C=CC3NC=NC=3C=2)=C(OC)C=1.[NH2:44][CH:45]1[CH2:53][C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[CH2:46]1>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[CH:18]=[CH:17][C:14]([CH2:15][NH:44][CH:45]4[CH2:53][C:52]5[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=5)[CH2:46]4)=[CH:13][C:12]=3[O:19][CH3:20])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 763102-AminoindaneHCID 178492558HCID 178492558, compoundHCID 178492632HCID 178492632, compound

Product 1

HCID 178492108HCID 178492108, compound

Procedure

N-{[4-(1H-Benzimidazol-5-yloxy)-3-(methyloxy)phenyl]methyl}-2,3-dihydro-1H-inden-2-amine was prepared using a mixture of 4-(1H-benzimidazol-5-yloxy)-3-(methyloxy)benzaldehyde and 5-{[4-[bis(methyloxy)methyl]-2-(methyloxy)phenyl]oxy}-1H-benzimidazole and the procedure of General method 1, step 5 where 2-aminoindane is the amine.

Sources & evidence

ORD record
ord-d4a7519b45c946888ae933742a65f57a
Source dataset
uspto-grants-2011_05
Patent number
US07939528B2

Reaction notes

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