HCID 86628100, compound → HCID 86628099, compound

Participants

Reaction Steps

1,1-dimethylethyl({4-[(3-amino-2,6-difluoro-4-nitrophenyl)oxy]phenyl}methyl)2,3-dihydro-1H-inden-2-ylcarbamate (114 mg) was dissolved in ethyl acetate and hydrogenated over 10% Pd on carbon (wet, degussa type) with Parr hydrogenator at 45 psi. The catalyst was removed by filtration through celite. The filtrate was concentrated to give [2-amino-4-({4-[(2,3-dihydro-1H-inden-2-ylamino)methyl]phenyl}oxy)-3,5-difluorophenyl]amine which was used without further purification.

Provenance & Evidence