Acetic Acid → HCID 57585899, compound

Participants

Reaction Steps

A solution of 2,2,2-trifluoro-N-{4-fluoro-5-[(4-formylphenyl)oxy]-2-nitrophenyl}acetamide (0.300 g, 0.806 mmol), 2-aminoindane (0.161 g, 1.21 mmol), and acetic acid (0.5 mL) in CH2Cl2 (3 mL) was stirred for 30 min and then Na(OAc)3BH (0.205 g, 0.967 mmol) was added slowly over 2 min. The reaction mixture stirred for 1 hour at ambient temperature and then H2O (3 mL) was added. The layers were separated and the aqueous layer extracted one additional time with CH2Cl2. The combined organics were washed 1× brine, then dried (Na2SO4), filtered and concentrated to give ({4-[(5-Amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)2,3-dihydro-1H-inden-2-ylamine. No further purification was necessary.

Provenance & Evidence