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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54768Generated: October 30, 2026

Isopropanol hydrochloride → trans-(+/-)-Tetrahydro-5-(phenoxymethyl)-3-furanthiol

https://huagongshe.com/reaction/54768

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsopropanol hydrochlorideHCID 21912024—
ReactantSodium methanolate methanolHCID 23694274—
ReactantEthanethioic acid trans-(+/-)-S-[tetrahydro-5-(phenoxymethyl)-3-furanyl]-esterHCID 86750316—
SolventTetrahydrofuranHCID 8028—
Producttrans-(+/-)-Tetrahydro-5-(phenoxymethyl)-3-furanthiolHCID 8675031570.1%

Reaction Steps

The title compound is prepared by the procedure of Example 16 using 0.532 g of product from Example 23, 506 microliter of 25% sodium methoxide/methyl alcohol, 7.5 ml of tetrahydrofuran, and 1.18 ml of 1.86N hydrochloric acid/isopropyl alcohol to give 0.311 g of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05623081
Source datasetuspto-grants-1997_04
ORD IDord-8c4c5437d8414dc68d5a8feb9e0665dd
Source noteuspto-grants-1997_04