反应详情

温度

140 °C

A mixture of 0.10 g (0.20 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(4-fluoro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide and 0.45 g (6.0 mmol) 2-(methylamino)ethanol was stirred 6 h at 140° C. After cooling to room temperature the reaction mixture was partitioned between water and tert-butyl methyl ether and extracted with three portions of tert-butyl methyl ether. The combined organic extracts were washed with a saturated aqueous solution of ammonium chloride and water, dried over sodium sulfate and concentrated in vacuo. Flash column chromatography gave 87 mg (78%) of the title compound as a light yellow solid.

1. temperatureAfter cooling to room temperature the reaction mixture
2. customwas partitioned between water and tert-butyl methyl ether
3. extractionextracted with three portions of tert-butyl methyl ether
4. washThe combined organic extracts were washed with a saturated aqueous solution of ammonium chloride and water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo