Imidazole → (Dimethoxyphosphinyl)[[(1,1-dimethylethyl)dimethylsilyl]oxy]acetic acid (4-nitrophenyl)methyl ester

Participants

Reaction Steps

To a mixture of 3.48 g of product from Example 97 and 12 ml of dimethylformide is added 1.86 of t-butyldimethylsilyl chloride and 1.86 g of imidazole. After stirring the reaction at room temperature for 2 hours, the mixture is diluted with 50% ethyl acetate/diethyl ester, washed 5 times water, once with saturated solid bicarbonate and once with saturated solid chloride. The organic layer is dried, filtered and concentrated in vacuo to give 3.90 g of the desired silylated product.

Provenance & Evidence