化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → HCID 52920347、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Homoproline, (+)- | HCID 2761541 | — |
| 反応物 | 4'-(3-Bromo-benzyloxy)-4,5-difluoro-2-methoxy-biphenyl | HCID 67153750 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | HCID 52920347 | HCID 52920347 | 46% |
反応手順
4′-(3-Bromo-benzyloxy)-4,5-difluoro-2-methoxy-biphenyl (142 mg, 0.35 mmol), copper(I) iodide (40 mg, 0.21 mmol), sodium iodide (105 mg, 0.70 mmol), cesium carbonate (687 mg, 2.1 mmol) and (S)-pyrrolidin-2-yl-acetic acid (106 mg, 0.78 mmol) and DMSO (0.35 ml) were reacted as above to yield 73 mg of {(S)-1-[3-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-acetic acid as a white solid. LC-MS (ES) calculated for C26H25F2NO4, 453.18; found m/z 454 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07939569B1 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-01e99890f9da43b2bb47289c2ca807ae |
| 出典メモ | uspto-grants-2011_05 |