HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → 5-(Azidomethyl)tetrahydro-3-thiophenethiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Ethanethioic acid S-[5-(azidomethyl)tetrahydro-3-thienyl]ester | HCID 54464306 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Azidomethyl)tetrahydro-3-thiophenethiol | HCID 18924039 | 20.7% |
Reaction Steps
A 0° C. solution, under argon, of 0.279 g of product from Example 141 in 3 ml of dry methyl alcohol is treated with 0.35 ml of 4.35M sodium methoxide. After 2 hours, the reaction mixture is concentrated in vacuo and the residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane) to give 0.0465 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623081 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-586d8aa41bf84e4aa9d16682505234d4 |
| Source note | uspto-grants-1997_04 |