Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Vanillin | HCID 1183 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(2-Methanesulfonyl-ethyl)-4-methyl-thiazole | HCID 18455442 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18455223 | HCID 18455223 | — |
Reaction Steps
Vanillin (2.9 mmol) was added to mixture of K2CO3 (14.5 mmol) and 5-(2-Methanesulfonyl-ethyl)-4-methyl-thiazole (5) (2.9 mmol) in DMF (0.2 M), and heated to 75° C. for 16 h. After cooling, water was added and aqueous mixture extracted 5 times with methylene chloride. The methylene chloride layers were combined and concentrated to afford the product (6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07939657B2 |
|---|
| Source dataset | uspto-grants-2011_05 |
|---|
| ORD ID | ord-cab8c80faf54487ab4fb736e2508b8f1 |
|---|
| Source note | uspto-grants-2011_05 |
|---|
