HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(piperidin-4-yl)pyridin-3-amine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-[(pyridin-3-yl)amino]piperidine-1-carboxylate | HCID 22499486 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(piperidin-4-yl)pyridin-3-amine dihydrochloride | HCID 67195943 | — |
Reaction Steps
A solution of 4-(pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.37 g, 5.00 mmol) in dioxane (20 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 178.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939661B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-775118b0e2374af5b3eae8074d65f6c6 |
| Source note | uspto-grants-2011_05 |