反应详情

To a suspension of 2-methyl-5-nitroanisole F1 (1.54 g; 9.21 mmol) in absolute ethanol (15 mL) was added 10% Pd/C catalyst (249 mg). The suspension was hydrogenated under a hydrogen filled balloon at atmospheric pressure and room temperature for 6.5 h. The reaction mixture was filtered through a Millex 0.45 micron filter and evaporated to dryness to provide 4-methyl-m-anisidine F2 (1.22 g; 8.89 mmol; 97% yield)

1. customat atmospheric pressure and room temperature
2. customfor 6.5 h
3. filtrationThe reaction mixture was filtered through a Millex 0.45 micron
4. filtrationfilter
5. customevaporated to dryness