HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → (+/-)-Ethanethioic acid S-[5-(2,4-difluorophenyl)tetrahydro-3-furanyl]ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Reactant | (+/-)-4-Bromo-2-(2,4-difluorophenyl)tetrahydrofuran | HCID 85719042 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | (+/-)-Ethanethioic acid S-[5-(2,4-difluorophenyl)tetrahydro-3-furanyl]ester | HCID 85719043 | 76.7% |
Reaction Steps
The title compound is prepared by the procedure of Example 5 using 1.9 g of product from Example 165, 0.866 g of potassium thioacetate and 30 ml of acetonitrile to give, after chromatography (silica gel: 5% ethyl acetate/hexane), 1.43 g of the desired product, as a mixture of isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623081 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-51ab1cf65f604334b15f0b666aec0cde |
| Source note | uspto-grants-1997_04 |