tert-Butyl methyl ether → HCID 67203600, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1,6-di-(tert-butoxycarbonyl)-ergoline-8β-carboxylic acid (300 g) in methanol (1.2 L) is slowly added thionyl chloride (94 g). The mixture is slowly heated to 50-55° C. and stirred until reaction completion (ca. 4-5 h). The resulted suspension is cooled to room temperature and to it is added methyl t-butyl ether (600 mL) and heptanes (1.8 L). The suspension is further cooled to 0-5° C. Filtered and washed with methyl t-butyl ether. The isolated solid is dried to give methyl ergoline-8β-carboxylate hydrochloride (190.5 g) in 94.5% yield.

Provenance & Evidence