HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Alanine → [(4-Nitrophenyl)methylcarbonyl]-L-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Alanine | HCID 5950 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester | HCID 21829967 | — |
| Product | [(4-Nitrophenyl)methylcarbonyl]-L-alanine | HCID 28215877 | — |
Reaction Steps
The title compound is prepared by the procedure of Example 255 using 5.3 g of product from Example 254, 1.48 g of L-alanine, 4.6 ml of triethylamine, and 200 ml of 80/20 ethyl alcohol/water. The resulting oil is purified by chromatography (3×, silica gel: 50% ethyl acetate/hexane) to give 3.39 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623081 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-1e8682eabc2d4a8fbe646d0123190478 |
| Source note | uspto-grants-1997_04 |