反应详情

After a suspension of 5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

1. washwas washed with 3N sodium hydroxide (50 ml)
2. extractionthe aqueous layer was extracted with chloroform
3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
4. distillationThen, the solvent was distilled off