HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57419852, compound → HCID 57944916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57419852 | HCID 57419852 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | HCID 57944916 | HCID 57944916 | 22% |
Reaction Steps
Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-(bromomethyl)-1,5-dimethyl-1H-pyrazole. Yield: 22%. MS M+H calculated 384.1; found 384.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.3 uM
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939671B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-2bf5d979dd564c05a58ba136ddc0ba85 |
| Source note | uspto-grants-2011_05 |