HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Xylyl bromide → HCID 57422451, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Xylyl bromide | HCID 7721 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | HCID 57422451 | HCID 57422451 | — |
Reaction Steps
Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 1-(bromomethyl)-4-methylbenzene. Yields 25%. MS M+H calculated 380.1; found 380.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.06 uM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939671B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-faa4fbf3d3e64c458b9f916ac0511fa4 |
| Source note | uspto-grants-2011_05 |