HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenethyl bromide → HCID 57944926, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenethyl bromide | HCID 2756964 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | HCID 57944926 | HCID 57944926 | 24% |
Reaction Steps
Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 2-fluorophenethyl bromide. Yield: 24%. MS M+H calculated 398.16; found 398.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.13 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939671B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-7fffb268a8ab4f4ba2038682bcf0551c |
| Source note | uspto-grants-2011_05 |