HCID 86624048, compound → HCID 86624047, compound

HRID 548200Notes

Reaction equation

HRID 548200 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][O:7][CH2:8][CH:9]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10][NH:11][C:12](=[O:21])[CH:13]=[CH:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1.[H][H]>C(O)C.[Pd].[C]>[F:33][C:31]([F:32])([F:34])[C:29]1[CH:28]=[C:5]([CH:4]=[CH:3][C:30]=1[C:31]([F:34])([F:33])[F:32])[CH2:6][O:7][CH2:8][CH:9]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10][NH:11][C:12](=[O:21])[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][N:18]=[CH:19][CH:20]=1

Participants

5

Reactant 2

HCID 86624048HCID 86624048, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86624047HCID 86624047, compoundYield 131.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Compound 45 (4.00 g, 7.8 mmol) was dissolved in ethanol (100 mL), a 5% Pd-carbon catalyst (0.5 g) was added thereto and the mixture was stirred for 20 hours in a hydrogen atmosphere. After the catalyst was filtered off, the filtrate was evaporated in vacuo and the crystals separated out therefrom were filtered after addition of petroleum ether to give the Compound 48 (2.61 g, 66%).

Workup

  1. filtrationAfter the catalyst was filtered off
  2. customthe filtrate was evaporated in vacuo
  3. customthe crystals separated out
  4. filtrationtherefrom were filtered
  5. additionafter addition of petroleum ether

Sources & evidence

ORD record
ord-1a485a4d0bd947aeb051de098f8256a8
Source dataset
uspto-grants-2011_05
Patent number
US07939552B2

Reaction notes

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