Ethanol → HCID 86624049, compound

HRID 548201Notes

Reaction equation

HRID 548201 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][C:30]=1C(F)(F)F)[CH2:6][O:7][CH2:8][CH:9]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10][NH:11][C:12](=[O:21])[CH2:13][CH2:14]C1C=CN=CC=1.[CH2:37](O)[CH3:38]>[Pd].[C]>[F:1][C:2]([F:36])([F:35])[C:29]1[CH:28]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:35])[F:36])[CH:30]=1)[CH2:6][O:7][CH2:8][CH:9]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10][NH:11][C:12](=[O:21])[CH2:13][CH2:14][C:9]1[CH:10]=[N:11][CH:12]=[CH:37][CH:38]=1.[F:1][C:2]([F:36])([F:35])[C:29]1[CH:28]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:35])[F:36])[CH:30]=1)[CH2:6][O:7][CH2:8][CH:9]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10][NH:11][C:12](=[O:21])[CH:13]=[CH:14][C:9]1[CH:10]=[N:11][CH:12]=[CH:37][CH:38]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 86624047HCID 86624047, compound

Product 2

HCID 86624049HCID 86624049, compoundYield 90%HCID 86624050HCID 86624050, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

In the same manner as in the case of synthesis of Compound 48, Compound 49 (3.61 g, 90%) was produced as crystals from Compound 46 (4.00 g, 7.8 mmol), 5% Pd-carbon catalyst (0.5 g) and ethanol (100 mL).

Sources & evidence

ORD record
ord-6b312ebfdea44983ac6ffb8386b1f331
Source dataset
uspto-grants-2011_05
Patent number
US07939552B2

Reaction notes

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