HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzoic Acid → N-[3-(3,5-bis(trifluoromethyl)benzyloxy)-2-phenylpropyl]-4-hydroxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzoic Acid | HCID 135 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(3,5-Bis(trifluoromethyl)benzyloxy)-2-phenylpropylamine hydrochloride | HCID 86624040 | — |
| Reactant | 1-Benzyl-4-[3-(3,4-bis(trifluoromethyl)-benzyloxy)-2-p henylpropylcarbamoyl]pyridinium chloride | HCID 86624042 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[3-(3,5-bis(trifluoromethyl)benzyloxy)-2-phenylpropyl]-4-hydroxybenzamide | HCID 86624051 | 61.3% |
Reaction Steps
In the same manner as in the case of synthesis of Compound 30, a residue was given from 4-hydroxybenzoic acid (0.33 g, 2.4 mmol), the compound produced in Example 17 (0.83 g, 2.0 mmol), triethylamine (0.28 mL, 2.0 mmol), WSC.HCl (0.46 g, 2.4 mmol) and CH2Cl2 (10 mL). The oily residue was crystallized from petroleum ether to give the Compound 56 (0.61 g, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939552B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-208da2d06529414e8797a1e9beff0c0a |
| Source note | uspto-grants-2011_05 |