1,4-Dioxane hydrochloride → HCID 86624060, compound

HRID 548208Notes

Reaction equation

HRID 548208 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[CH2:6][O:7][CH2:8][CH:9]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:10][NH:11][C:12]([CH2:14][CH2:15][NH:16]C(=O)[O-])=[O:13].[ClH:35].O1CCOCC1>O1CCOCC1>[ClH:35].[NH2:16][CH2:15][CH2:14][C:12]([NH:11][CH2:10][CH:9]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[CH2:8][O:7][CH2:6][C:5]1[CH:26]=[C:27]([C:29]([F:30])([F:32])[F:31])[CH:28]=[C:3]([C:2]([F:1])([F:33])[F:34])[CH:4]=1)=[O:13]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86624062HCID 86624062, compound

Product 1

HCID 86624060HCID 86624060, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound 73 (1.32 g, 2.4 mmol) produced in Example 95 was dissolved in dioxane (4 mL) and 4 mol/L hydrogen chloride/dioxane (4 mL) was added thereto at room temperature. After the mixture was stirred for 20 hours, the solvent was evaporated therefrom in vacuo. Ether was added to the resulting residue to crystallize whereupon Compound 74 (1.10 g, 95%) was produced.

Workup

  1. customat room temperature
  2. customthe solvent was evaporated
  3. additionEther was added to the resulting residue
  4. customto crystallize whereupon Compound 74 (1.10 g, 95%)
  5. customwas produced

Sources & evidence

ORD record
ord-9b028a0f18f940188f4e48757240e4b6
Source dataset
uspto-grants-2011_05
Patent number
US07939552B2

Reaction notes

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